In Romania, the incidence of CRC in is colorectal cancer progression We reviewed a series of studies that are related to colon cancer and studied the epithelial-mesenchymal transition at the front of tumor invasion EMT. Cellular phenotypic changes characteristic colorectal cancer progression EMT can be induced by the absence of transition cofactor p involved in cellular regulation.
Loss of syndecan-1 marker is associated with local tumor stage and metastasis. Modulators of protein kinase resistance was associated with changes in genes involved in EMT including vimentin hyperexpression and genes involved in invasion N-cadherin with a decrease expression of genes involved in epithelial cell adhesion E-cadherin.
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- Dan G. Duda - DF/HCC
- EBSCOhost | | MARKERS OF ANGIOGENESIS IN RECTAL CANCERS.
Progression in colon cancer is characterized by activating mutations in Ras genes and tumor growth factor action. Vimentin expression colorectal cancer progression with EMT initiates molecular program. One of the characteristics colorectal cancer progression EMT is the loss of E-cadherin.
TGF-β transforming growth factor beta induces epithelial-mesenchymal transition in colon cancer cell lines with the microsatellite stability, inducing cell invasion and migration. EMT is a critical early event involved in invasion and metastasis of colorectal cancer, characterized by the presence of markers specific to each phenotype, epithelial or mesenchymal.
Multiple biomarkers involved in the induction of EMT may represent future therapeutic target in the treatment of colonic neoplasia.
- J Gastrointestin Liver Dis ; 25 3 :Sep.
- Duda's group is focused on studies of tumor interaction with its microenvironment, with the goal of identifying the cellular and molecular mechanisms of: 1 local tumor progression in liver cancers and metastatic tumor progression in other gastrointestinal cancers and in prostate and breast malignanciesand 2 treatment resistance in advanced cancers.
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Glimelius B, Oliveira J. Rectal cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up.
Ann Onc ; Miron L, Marinca M. Tratamentul sistemic al cancerului colorectal metastatic: standarde actuale, opţiuni viitoare. J Chir Iasi ; 3: Hopulele D.
Relaţia între markerii biologici ai agresivităţii tumorale şi infiltratul inflamator în cancerul mamar. Teză de doctorat.
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Facultatea de Medicină. UMF Iaşi EMT is the dominant program in human colon cancer.
Tipuri[ modificare modificare sursă ] Un neoplasm poate fi benign, potențial malign sau malign cancer. Sunt circumscrise și localizate, și nu se transformă în cancer.
BMC Med Genomics ; 4: 9. Absence of p induces cellular phenotypic changes char-acteristic of epithelial to mesenchyme transition.
Source: Fiziologia - Physiology.
Brit J Cancer ; — Four-and-a-half LIM protein 2 promotes invasive potential and epi-thelial mesenchymal transition in colon cancer. Carcinogenesis Association of loss of epithelial syndecan-1 with stage and local metastasis of colorectal adenocarcinomas: An immunohistochemical study of clinically annotated tu-mors.
BMC Cancer ; Preclinical and clinical development of novel agents that target the protein kinase C family. Semin Oncol ; — Nishizuka Y.
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