Does hpv cause other cancers


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The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and E7 oncoproteins are the critical molecules in the process of malignant tumour formation. Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion does hpv cause other cancers regulation of immune responses.

High-risk E6 does hpv cause other cancers E7 bind to p53 and pRb and inactivate their functions with dysregulation of the cell cycle. Uncontrolled cell proliferation leads to increased risk of genetic instability.

Usually, it takes decades for cancer to develop.

Traducerea «HPV» în 25 de limbi

This review presents the main mechanisms of HPV genome in the carcinogenesis of the uterine cervix. Virusul infectează epiteliile bazale, celule de epiteliu scuamos stratificat.

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Proteinele celulare E6 și E7 influențează fundamental funcțiile celulare, cum ar fi reglarea ciclului celular, întreținerea telomerilor, susceptibilitatea la apoptoză, adeziunea intercelulară și reglarea răspunsurilor imune. E6 și E7 cu grad ridicat de risc se leagă la p53 și PRB și inactivează funcțiile lor cu dereglarea ciclului celular. Proliferarea necontrolată a celulelor conduce la un risc crescut de instabilitate genetică.

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De obicei, este nevoie de zeci de ani pentru a dezvolta un cancer. Acest review prezintă principalele mecanisme ale genomului HPV în carcinogeneza colului uterin.

  • Pentru majoritatea oamenilor, virusul papilomavirus uman HPV dispare de la sine, în mod spontan.
  • According to some recent studies, the HPV infection may also increase the risk of cardiovascular diseases.
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The most important risk factor in the ethiology of cervical cancer is the persistent infection with a high-risk strain of human papillomavirus. Materials and methods This general review was conducted based on the AngloSaxone literature from PubMed and Medline to identify the role of HPV genome in the development of cervical cancer.

Discussions Genital human papillomavirus HPV is the most common sexually transmitted infection. Although the majority of infections cause no symptoms and are self-limited, persistent infection with high-risk types of HPV is the most important risk factor for cervical cancer precursors and invasive cervical cancer.

The presence of HPV in They are also responsible for others genital neoplasias like vaginal, vulvar, anal, and penian.

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HPV is a non-enveloped, double-stranded DNA virus from the family of Papillomaviridae, with an 8 kb circular genome composed of six early ORFs open reading frames with role in viral transcription and replication E1, E2, E4, E5, E6, E7two late ORFs L1,2-capsid proteins and a non-coding long controlled region LCR that contains a variety of cis elements, which regulate viral replication and gene expression.

More than HPV types have been identified, and about 40 can infect the genital tract.

does hpv cause other cancers

Based on their association with cervical cancer and precursor lesions, HPVs are grouped to high-risk 16, 18, 31, 33, 34, 35, 39, 45, 51, 52, 56, 58, does hpv cause other cancers, 66, 68, 73, 82 and low-risk HPV types 6, 11, 42, 43,  44, 54, 61, 70, 72, Natural history Most genital HPV infections are benign, subclinical, and self-limited, and a high proportion of does hpv cause other cancers associated with low-grade cervical dysplasias also regress spontaneously 1. By contrast, persistent cervical infection infection detected more than once in an interval of 6 months or longer with an oncogenic HPV type, especially HPV 16 and HPV 18, is the most important risk factor for progression to high-grade dysplasia, a precancerous lesion that should be treated to prevent the development of wart on foot with black spots cancer 2.

Înțelesul "HPV" în dicționarul Engleză

HPV is a necessary but not a sufficient condition for the does hpv cause other cancers of cervical cancer. Cofactors associated with cervical cancer include: cigarette smoking, increased parity, increased age, other sexually transmitted infections, immune suppression, long-term oral contraceptive use, and other host factors.

Figure 1. Schematic representation of the HPV double-stranded circular DNA genome Journal of Virology Nov HPV integration into the host genome and Papillomavirus life cycle To establish infection, the virus must infect basal epithelial cells of stratified does hpv cause other cancers epithelium, that are long lived or have stem cell-like properties. Microtrauma of the suprabasal epidermal cells enables the virus to infect the does hpv cause other cancers within the basal layer.

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Once inside the host cell, HPV DNA replicates as the basal cells differentiate and progress to the surface of the epithelium. The viral genome maintains itself as an episome in basal cells, where the viral genes are poorly expressed.

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In the differentiated keratinocytes of the suprabasal layers of the epithelium, the virus switches to a rolling-circle mode of DNA replication, amplifies its DNA to high copy number, synthesizes capsid proteins, and causes viral assembly does hpv cause other cancers occur 3.

HPV needs host cell factors to regulate viral transcription and replication.

Sinonimele și antonimele HPV în dicționarul de sinonime Engleză

Their function is to subvert the cell growth-regulatory pathways by binding and inactivating tumor suppressor proteins, cell cyclins, and cyclin-dependent kinases and modify the cellular environment in order to facilitate viral replication in a cell that is terminally differentiated and has exited the cell cycle 4.

Cell growth is regulated by two cellular proteins: the tumor suppressor protein, p53, and the retinoblastoma gene product, pRB. Unlike in many other cancers, the p53 in cervical cancer is usually wild type and is not mutated.

E6  binds to p53 via a cellular ubiquitin ligase named E6AP, so that it becomes ubiquitinated, leading to degradation and down-regulation of pathways involved in cycle arrest  and apoptosis.

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This degradation has the same effect as an inactivating mutation. It is likely that ubiquitin ligase E6AP is a key player not only in the degradation of p53 but also in the activation of telomerase and cell transformation by E6 5.

does hpv cause other cancers

The E7 binds to retinoblastoma RBphosphorylating and therefore inactivating it 4. Also it binds to other mitotically interactive cellular proteins such as cyclin E.

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Rb prevents inhibiting progression from the gap phase to the synthesis phase of the G1 mytotic cycle. When E7 binds to and degrades Rb protein, it is no longer functional and cell proliferation is left unchecked.

The outcome is stimulation of cellular DNA synthesis and cell proliferation.

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The net result of both viral products, E6 and E7, is dysregulation of the cell cycle, allowing cells with genomic defects to enter the S-phase DNA replication phase. These oncoproteins have also been shown to promote chromosomal instability as well as to induce cell growth and immortalize cells.

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Next, the E5 gene product induces an increase in mitogen-activated protein kinase activity, thereby enhancing cellular responses to growth and differentiation factors. This results in continuous proliferation and delayed differentiation of the host cell. The E1 and E2 gene products are synthesized next, with ossiuri rimedi naturali role in the genomic replication.

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Through its interaction with E2, E1 is recruited to the replication origin oriwhich is essential for the initiation of viral DNA replication.

E2 also contributes to the segregation of viral DNA in the cell division process by tethering the viral DNA to the host chromosome through interaction with Brd4. Segregation of the viral genome is essential to maintain the HPV infection in the basal cells, in which the copy number of the viral genome is very low.