More commonly identified coagulopathies include von Willebrand disease vWD and other disorders of platelet function. Thursday, December 30, In women endometrial cancer fertility preservation abnormal bleeding and normal pelvic anatomy, rates of vWD were found to be 13 percent Shankar, The disorder is more common in Caucasian than in African-American women Miller, Patients with vWD commonly complain of menorrhagia, and rates of 60 to 70 percent have been noted Kadir,; Lak, Heavy menstruation begins with menarche in these patients.
Importantly, vWF levels may be higher during the luteal phase, and thus samples should be obtained prior to day 7 of the menstrual cycle Kadir, ; Lee, Treatments for women with menorrhagia and vWD include desmopressin, plasma concentrates, hormonal contraception, antifibrinolytics, and surgery. Combination oral contraceptive pills have been noted to arrest uterine hemorrhage in 88 percent of women Foster, Also, Kingman and co-workers reported that the LNG-IUS effectively decreased blood loss and induced amenorrhea in 56 percent of women with inherited bleeding disorders.
Preliminary success has been found with endometrial ablation for women with vWD-related menorrhagia El-Nashar, ; Rubin,