- Abstract: Despite the significant progress regarding molecular classifications for colon, pancreatic and gastric cancer, the therapeutic methods arterial, chimio and radioembolizationthe life expectancy of patients with existing liver metastases did not improve significantly.
- Cainap Calin - Referințe bibliografice Google Academic
Hericium erinaceus HE has been used for the treatment of digestive diseases for over years in China. HE possesses many beneficial functions such as anticancer, antiulcer, antiinflammation and antimicrobial effects, immunomodulation and other activities. The aim of gastric cancer metastasis to liver studies was to evaluate the anticancer efficacy of two extracts HTJ5 and HTJ5A from the culture broth of HE against three gastrointestinal cancers such as liver, colorectal and gastric cancers in both of in vitro of cancer cell lines and in vivo of tumor xenografts and discover cirugia cancer laringe active compounds.
Tumor volumes and body weight were measured daily during the first 10 days and times a week thereafter to assess the tumor growth inhibition, tumor doubling time, partial and complete tumor response and toxicity.
They are more effective and less toxic compared to 5-FU in all four in vivo tumor models. However, further studies are required to find out the active chemical constituents and understand the mechanism of action associated with the super in vivo anticancer efficacy.
In addition, future studies are needed to confirm our preliminary results of in vivo synergistic antitumor efficacy in animal models of tumor xenografts with the combination of HE extracts and clinical used anticancer drugs such as 5-FU, cisplatin and doxurubicin for the treatment of gastrointestinal cancers. This study investigated whether dihydroartemisinin DHAa semi-synthetic derivative of artemisinin, could inhibit the growth of gastric cancer both in vitro and in vivo.
A series of in vitro experiments including MTT, colony-forming, wound healing, invasion, cell cycle, cellular senescence, and apoptosis assays were performed to examine the antiproliferative and antimetastatic effects of DHA on three gastric cancer cell lines, SGC, BGC, and MGC The result showed that the proliferation rate and colony-forming abilities gastric cancer metastasis to liver gastric cancercells were significantly suppressed by DHA together with significant suppression of the expressions of proliferation markers PCNA, cyclin E, and cyclin D1and upregulation of p21 and p Moreover, DHA induced cellular senescence, G1 phase cell cycle arrest and hindered the migration and invasion of gastric cancer cells corresponding with downregulation of MMP-9 and MMP Treatment of gastric cancer cells with DHA increased miRb and miR expression, caused a downregulation of Bcl-2, resulting in apoptosis of gastric cancer cells.
In summary, we have shown that DHA is able to inhibit the growth and metastasis of human gastric cancer.
- Abstract Aim: Malignant tumors localized in the digestive tract have a tendency to local growth and invasion with lymph node metastasis.
- Duda's group is focused on studies of tumor interaction with its microenvironment, with the goal of identifying the cellular and molecular mechanisms of: 1 local tumor progression in liver cancers and metastatic tumor progression in other gastrointestinal cancers and in prostate and breast malignanciesand 2 treatment resistance in advanced cancers.
- CONSUMPTION OF ALCOHOLIC BEVERAGES - Personal Habits and Indoor Combustions - NCBI Bookshelf
Our work suggested that DHA has significant anticancer effects against gastric cancer both in vivo and in vitro, indicating that it is a promising therapy for human gastric cancer. Resveratrolul este un polifenol apărut pe cale gastric cancer metastasis to liver cu puternică acţiune de inducere a apoptozei.
Cu toate acestea mecanismele care stau la baza acţiunilor sale rămân necunoscute. Aceste date furnizează probe că resveratrolul induce apoptoza via ROS, dar independent de sirtuina1, la linia celulară a cancerului gastric uman SGC Acest studiu investighează faptul dacă dihidroartemisininul DHAun derivat semi-sintetic al artemisininului, poate inhiba dezvoltarea cancerului gastric atât in vivo cât şi in vitro.
MALIGNANT TUMORS OF DIGESTIVE ORGANS AND LIVER METASTASES AT THE TIME OF DIAGNOSIS
Au fost desfăşurate o serie de experimente in gastric cancer metastasis to liver, incluzând MTT, formarea de colonii, vindecarea unor răni, invazie, ciclu celular, îmbătrânire celulară şi teste de apoptoză, pentru a examina efectele anti-proliferative şi anti-metastatice ale DHA asupra a trei gastric cancer metastasis to liver celulare ale cancerului gastric, SGC, BGC şi MGC Rezultatele au arătat că rata de proliferare şi abilitatea de a forma colonii ale celulelor canceroase gastrice au fost semnificativ supresate de DHA odată cu o supresare semnificativă a expresiei markerilor de proliferare PCNA, ciclina Anemie hipocroma microcitara şi ciclina D1 şi hiperreglarea lui p21 şi p Mai mult decât atât, DHA a indus senescenţă celulară, stoparea ciclului celular în faza G1 şi a împiedicat migraţia şi invazia celulelor canceroase gastrice cu hiporeglarea lui MMP-9 şi MMP Tratamentul celulelor gastrice cu Gastric cancer metastasis to liver a crescut expresia miRb şi miR şi a cauzat o hiporeglare a Bcl-2, rezultând apoptoza celulelor canceroase gastrice.
În rezumat am arătat că DHA este capabil să inhibe dezvoltarea şi metastazele cancerului gastric uman.
Since that time, new data have become available, these have been incorporated into the Monograph, and taken into consideration in the present evaluation. Exposure Data 1.
Munca noastră sugerează că DHA are efecte semnificative anti-cancer asupra cancerului gastric atât in vivo cât şi in vitro, indicându-l ca pe un tratament promiţător pentru cancerul gastric la oameni. Tartalom betöltés