Gastric cancer with bone metastasis

Abstract: Despite the significant progress regarding molecular classifications for colon, pancreatic and gastric cancer, the therapeutic methods arterial, chimio and radioembolizationthe life expectancy of patients with existing liver metastases did not improve significantly.

The aim was to analyze the interrelation between the vascularization, mast cells and the histological growth pattern of hepatic metastasis with digestive origins.

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The distribution of the liver metastasis growth pattern was as follows: colon all 3 typespancreatic replacementgastric pushing type. A significant correlation between mast cell density in the peritumoral area and vascular microdensity in the metastatic domain of all histological growth patterns was found.

Significant correlation between positive mast cells tryptase density and degree of differentiation for the desmoplastic type was noticed. The mast cells may have a prognostic role in this growth pattern and the mast cell inhibitor therapy may be useful. Keywords: mast cells, liver metastasis, histological growth pattern References: 1.

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