Department of Ophthalmology, Grigore T. E-mail: moc.
Aim: To implement the HPV genotyping method of fresh head and neck cancer samples in our laboratory. More than half of the patients recognized being chronic alcohol and tobacco users.
Conclusions: The genotyping method was validated according to kit instructions. To get a general idea on the prevalence of HPV genotypes in head and neck cancer in our region we tested a very small number of samples.
Ferlay J, Soerjomataram I et al. Comprehensive control of human papillomavirus infections and related diseases.
Archive of Clinical Cases
Venuti A, Paolini F. Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas.
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Ursu RG, Danciu M et al. Virol J.
The biologic behavior of squamous cervical carcinoma after neoadjuvant therapy NAT according to immunohistochemical expression of E-cadherin and CD44v6 Mihaela Madalina Gavrilescu, Raluca Balan, Viorel Scripcariu, Dan Ferariu, Ludmila Lozneanu, Diana Popovici, Cornelia Amalinei Abstract The efficiency of neoadjuvant therapy in cervical carcinoma has been well demonstrated, although the cellular mechanisms of different response to this treatment have not been thoroughly investigated. The aim of our study was to assess the correlations between the alterations in E-cadherin and CD44v6 immunoexpression in cervical carcinoma, as a tool of evaluation the response to neoadjuvant therapy and its prognostic significance. The intensity of CD44v6 immunoexpression was higher in more aggressive tumors and E-cadherin immunoexpression was approximately constant among the cases with neoadjuvant therapy. Our results demonstrate that the evaluation of CD44v6 immunoexpression in cervical carcinomas is useful for the assessment of tumor response to neoadjuvant therapy and of tumor aggressiveness. The high level of E-cadherin immunoexpression in tumors with neoadjuvant therapy reflects its involvement in the prevention of HPV oncoproteins action, with benefits on the outcome.
Human papillomavirus prevalence in invasive laryngeal cancer in the United States. Shanesmith R, Allen RA et al.
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Comparison of 2 line blot assays for defining HPV genotypes in oral and oropharyngeal squamous cell carcinomas. HPV genotype distribution in oral and oropharyngeal squamous cell carcinoma using seven in vitro amplification assays. Garnaes E, Kiss K et al.
A high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, the largest registry-based study to date. Time trends in the prevalence of HPV in oropharyngeal squamous cell carcinomas in northern Spain Low human papillomavirus prevalence in head and neck cancer: results from two large case-control studies in high-incidence regions.
Westra WH. Heiduschka G, Grah A et al. Masterson L, Moualed D et al. De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma: a systema-tic review and meta-analysis of current clinical trials.