Rezumat: Bisphosphonates are effective against the increased bone resorption caused by certain diseases because they inhibit the activity of osteoclasts. In patients who have breast cancer and metastatic bone disease, the bisphosphonate clodronate clodronic acid reduces the frequency of skeletal complications.
Experiments in animals and preliminary clinical observations indicate that early clodronate therapy reduces the incidence of new bony metastases in breast cancer. We investigated the effects of clodronate on the incidence and papilloma seno cause of new metastases in patients with breast cancer.
METHODS: Between andpatients with primary breast cancer and tumor cells in the bone marrow the presence of which is a risk factor for the development of distant metastases were randomly assigned to receive clodronate at a dose of mg per day orally for two years patients or standard follow-up patients. The median length of observation was 36 months.
Aceste exemple pot conține termeni colocviali. Traducere "metastazare" în engleză Alte traduceri Datorită acestei legări, celula canceroasă nu mai poate primi mesajele de care are nevoie pentru creştere, dezvoltare şi metastazare.
All patients in both groups received standard surgical treatment and customary hormonal therapy or chemotherapy. RESULTS: Distant metastases were detected in 21 patients in the clodronate group and in 42 patients in the control group P Cuvinte cheie: breast cancer, bisphosphonates, adjuvant, clinical trial, clodronate.