Neuroendocrine cancer with mets. Most Downloaded Articles


NEUROENDOCRINE TUMORS: CHOOSING APPROPRIATE IMAGING METHODS

One of the major tools to evaluate this type of pathology is the neuroendocrine markers as chromogranin A, serotonin, urinary 5-hydroxy indolacetic acid, and neuron specific enolase. They change related to the disease progression, regardless therapy. Some of the drugs that are used for NETs as somatostatin analogs for example octreotide might interfere with glucose metabolism.

We analyzed in a retrospective study of 2 years the dynamic of the NET markers and the glycemia profile.

neuroendocrine cancer with mets

Material and Methods. All the patients had at least one assay per year. The dose of octreotide varied from 20 to 50 mg, monthly.

The fasting glucose insignificantly changed from baseline after 2 years.

MATERIALS AND METHODS: Imaging studies of 22 neuroendocrine cancer with mets 12 men, mean age 60 years with histopathologically confirmed diagnosis, evaluated in the authors's institution during the last five years were retrospectively reviewed by two radiologists, with findings being consensually described focusing on changes observed at computed tomography. Only one typical carcinoid presented the characteristic appearance of central endobronchial nodule with distal pulmonary atelectasis, while the others were pulmonary nodules or masses. The atypical carcinoids corresponded to peripheral heterogeneous masses.

No new case of diabetes was registered. One case of known diabetes needed insulin but interferon therapy was also added during this time period. The chromogranin A had sustained high values for all the 9 cases, marking the disease progression. Neuroendocrine cancer with mets neuron specific enolase significantly increased, and the serum serotonin as well as the 5HIIA was much higher in 2 cases with aggressive carcinoid symptoms.

The NET markers and the glucose metabolism are most useful tools in the management of NETs, yet they are not correlated. Rezumat Tumorile neuroendocrine NET sunt mult mai frecvente în ultimele decade.

Речь идет о засекреченной информации, хранящейся в личном помещении директора. Ты только представь себе, что будет, если об этом станет известно.

- Директор в Южной Америке. - Извини.

Unul din intrumentele majore de evaluare în această patologie este reprezentat de dozarea markerilor neuroendocrini precum cromogranina A, serotonina, acidul 5-hidroxi indolacetic urinar şi enolaza neuronal specifică. Aceştia se schimbă cu progresia tumorală, indiferent de terapie. O parte din medicamentele folosite în NET precum analogii de somatostatin de exemplu, octreotid interferă cu metabolismul glucozei.

Am analizat într-un studiu retrospectiv de-a lungul a 2 ani dinamica markerilor NET şi profilul glicemic.

Material si metode. Toţi pacienţii au avut cel puţin o neuroendocrine cancer with mets pe an.

Revista Romana de Medicina de Laborator

Doza de octreotid a variat de la 20 la 50 mg lunar. Glicemia s-a modificat nesemnificativ de la bază după 2 ani. Nu s-a neuroendocrine cancer with mets nici un caz nou de diabet. O pacientă a necesitat insulină pentru diabetul preexistent dar între timp s-a adaugat şi terapie cu interferon Cromogranina A a avut valori mari sustinute pentru toate cele 9 cazuri, sugerând progresia bolii.

Enolaza neuronal specifică a crescut semnificativ iar serotonina serică şi 5HIIA au crescut considerabil în 2 cazuri cu simptome severe de sindrom carcinoid.

viermi la copii 2 ani

Markerii NET şi metabolismul glucidic sunt instrumente foarte utile in managementul tumorilor neuroendocrine, totusi acestea nu se coreleaza. Cuvinte cheie: cromogranina A ; tumora neuroendocrina ; serotonina References 1.

NEUROENDOCRINE TUMORS: CHOOSING APPROPRIATE IMAGING METHODS | The Medical-Surgical Journal

Neuroendocrine tumors. Endocr Relat Cancer.

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DOI: Oberndorfer S. Karzinoide tumoren des dunndarms. Frank Z Pathol.

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  2. В центре лба зияло пулевое отверстие, из которого сочилась кровь, заливая лицо.

Google Scholar 3. Carcinoid Tumors. Bellizzi AM. Assigning site of origin in metastatic neuroendocrine neoplasms: a clinically significant application of diagnosis immunohistochemistry. Adv Anat Pathol. Chromogranins A, B, C: widespread consitituents of secretory vesicles.

Ann N Y Acad Sci.

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Chromogranin A, neuron specific enolase, carcinoembryonic antigen, and hydroxyindole acetic acid evaluation in patients with neuroendocrine neuroendocrine cancer with mets. Regul Pept. The poor prognosis factors in G2 neuroendocrine tumor. Rom J Morphol Embryol. Google Scholar The dedifferentiation of neuroendocrine tumor metastases: myth or reality?

This article provides an overview of the current state of the imaging modalities used for primary tumor visualization, staging and follow-up.