Papillary thyroid cancer presentation, [Differentiated thyroid cancer--peculiar morphological and clinical forms].


Case report: We report the case of a years-old female patient with personal history of cervical fistulizing tuberculous gumma diagnosed with right lateral cervical mass and Hashimoto nodular thyroiditis.

Abstract Aim: to describe two cases of familial papillary thyroid carcinoma. Material and methods: patients were investigated by fine needle biopsy, MRI imaging and tumor biopsy, first case and histological examination of colonic and thyroid tumors first case and histological examination of thyroid tumor second case.

Results and discussion: case presentation: first case, 68 years old man had a colonic polyposis attenuated form with only a few polyps and a papillary thyroid cancer presentation nodule. After hemicolectomy for a supposed colonic carcinoma with liver and lung metastases, histological examination revealed no malignant colonic disease. Two month later the diagnosis of invasive thyroid tumor with lymph node metastases was made, but only an open biopsy was done because tumor invasiveness demonstrated on MTI imaging.

The biopsy identified a papillary thyroid carcinoma. Case 2: the son of the patient 30 years old without known diseases was invited to be assessed for thyroid disease.

BiosciAbstracts

Ultrasound examination discovered a large nodule with microcalcifications. Microscopic examination done after total thyroidectomy revealed a cribriform morular variant of papillary thyroid carcinoma, a variant that is known to be associated with FAP.

papillary thyroid cancer presentation juvenile laryngeal papillomas

Radioiodine ablation was made followed by suppressive thyroxine treatment. In the second case papillary thyroid cancer presentation polyposis was not found yet.

papillary thyroid cancer presentation

In our knowledge these are the first cases of familial thyroid papillary carcinomas in our setting. Familial history allowed an earlier diagnosis and a good management of the disease in the second case.

Conclusions: according to the literature and our first experience, screening for thyroid cancer must be done in all patients with FAP virus papilloma sintomi in those with a FAP proband in the family. Nosé V. Endocr Pathol.

Modern Pathology ; SS Cavaco BM.

FAMILIAL SYNDROMIC PAPILLARY THYROID CARCINOMA - REPORT OF TWO CASES

Endocrine-Related Cancer ; Richards ML. Thyroid ; Nilbert M, Kristoffersson U, Ericsson M, et al: Broad phenotypic spectrum in familial adenomatous polyposis; from early onset and severe phenotypes to late onset of attenuated polyposis with the first manifestation at age BMC Med Genet.

Orphanet J Rare Dis ; 7. Histopathology ; Asian J Surg.

Imagine similară | Thyroid ultrasound, Thyroid, Thyroid nodules

Clin Gastroenterol Hepatol. Clin Colorectal Cancer ; 11 4 : Head Neck papillary thyroid cancer presentation Ann Surg. Kameyama K, Takami H. Fam Cancer. Lee S, Hong SW, Shin SJ,et al: Papillary thyroid carcinoma associated with familial adenomatous polyposis: molecular analysis of pathogenesis in a family and review of the literature.

[Differentiated thyroid cancer--peculiar morphological and clinical forms].

Endocr J. Am J Otolaryngol.

Thyroid Cancers

Cetta F. Acta Cytol. Kurihara K, Shimizu S, Chong J, et al: Nuclear localization of immunoreactive beta-catenin is specific to familial adenomatous polyposis in papillary thyroid carcinoma.

papillary thyroid cancer presentation

Jpn J Cancer Res. Ito Y, Miyauchi A, Ishikawa H, et al: Our experience of treatment of cribriform morular variant of papillary thyroid carcinoma; difference in clinicopathological features of FAP-associated and sporadic patients. Mc Donald TJ.

Endocrine Abstracts

Journal of Oncology. Nasr MR. Modern Pathology. Capezzone M.