Rectal cancer pathophysiology. OneSearch Results | University of Toronto Libraries

For quite some time, anal canal cancer rectal cancer was not regarded as an individual pathology, but it was seen, instead, as a form of rectal cancer.

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The limit between the rectum and the anal canal was set as the anorectal line dentate line. Thus, the anatomical anal canal is located between the dentate line proximally and the anocutaneous line distally.

Case report Conf. Daniela Moşoiu, Alexandru C. Grigorescu, Şef lucrări dr. Some of these patients address the doctors in locally advanced stages, sometimes without the possibility to perform resection.

In practice, upon the rectal touch, the anal canal is longer and it also includes the transitional cylindrical epithelium area located above the dentate line, the so-called surgical anal canal.

The surgical anal canal is the predilect anal canal cancer location region.

[Strategy and tactic in the treatment of local advanced rectal cancer].

Tumours located distally from the anocutaneous line are classified as perianal skin tumours. Pathology and Anatomy of the Anal Cancer: Because the anal canal structure hosts several types of epithelium flat polystratified, transitional epithelium, cylindrical epithelium of the rectum and glandular epithelium of the anal glands there are several types rectal cancer pathophysiology tumours epidermoid, mucoepidermoid, adenocarcinoma.

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The most frequently encountered anal canal and perianal region tumours are epidermoid tumours. They are frequent in the population above 50 years of age, but more often in women. Anal Cancer Clinical Presentation: The symptoms are present rectal cancer pathophysiology in the incipient stages of the disease.

rectal cancer pathophysiology

Symptoms such as: pain during or after defecation; bleeding; the sensation of foreign body in the anal or perianal canal; perianal pruritus itching ; unfinished stool sensation; are present almost constantly, from the very onset of the disease.

The fact that the symptoms are present from an incipient stage is explained by the rich anal canal innervation. The pain intensifies in time, as the mass increases in size.


The tumoral invasion in the sphincter leads to its destruction and to the appearance of the anal incontinence. The invasion in the posterior wall of the vagina causes rectovaginal fistula. In men, enterobius vermicularis guidelines prostate and urethra invasion causes dysuria.

Anal Cancer Symptoms The anal canal cancer symptoms are not specific and they are often interpreted as a benign rectal cancer pathophysiology canal pathology manifestation.

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  • [Strategy and tactic in the treatment of local advanced rectal cancer].
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Pain during or after defecation. In all cases in which there are suspicions, the rectal exploration, the anoscopy or the rectosigmoidoscopy with the biopsy of the tumour mass or suspected area are indicated.

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The palpation of the inguinal areas is recommended and, in case the lymph nodes are enlarged, they should be biopsied. How Is Anal Cancer Treated? Clear treatment principles are currently available.

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Colonoscopy accompanied by biopsy is the first step, as it provides the clear proof of the cancerous pathology. Once the rectal cancer diagnosis was set, the oncologist sets the suitable treatment protocol, which, in principle, starts with ionizing radiation therapy, in combination with chemotherapy or not.

The second stage of the surgical treatment then follows, which supposes the excision of the tumour and of the concerned large intestine segment. The lower resection limits have dropped a lot, i. Rectal cancer pathophysiology Appointments.

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