Since that time, new data have become available, these have been incorporated into the Monograph, and taken into consideration in the present evaluation.
Exposure Data 1. Types and ethanol content of alcoholic beverages 1.
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Types of alcoholic beverages The predominant types of commercially produced alcoholic beverages are beer, wine and spirits. Basic ingredients for beer are malted barley, water, hops and yeast. Wheat may be used. Nearly all wine is produced from grapes, although wine can be also made from other fruits and berries. Spirits are frequently produced from cereals e. Main beverage types i. In addition to commercialized products, in many developing countries different types of home- or locally produced alcoholic beverages such as sorghum beer, palm wine or sugarcane spirits are consumed WHO, Home- or locally produced alcoholic beverages are produced through fermentation of seed, grains, fruit, respiratory papillomatosis drug or parts of palm respiratory papillomatosis drug, by a fairly simple production process.
Alcohol content differs according to the respiratory papillomatosis drug beverage type and may also vary by country.
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However, lower or higher ethanol content in alcoholic beverages is also possible. The ethanol content in beer can range from 2.
There is a trend in recent years towards higher To calculate the amount of ethanol contained in a specific drink, the amount e.
Chemical composition The main components of most alcoholic beverages are ethanol and water. Services Reg. Volatile compounds include aliphatic carbonyl compounds, alcohols, monocarboxylic acids and their esters, nitrogen- and sulfur-containing compounds, hydrocarbons, terpenic compounds, and heterocyclic and aromatic compounds. Non-volatile extracts of alcoholic beverages comprise unfermented sugars, di- and tribasic carboxylic acids, colouring substances, tannic and polyphenolic substances and inorganic salts IARC, Occasionally, toxic additives, that are not permitted for use in commercial production have been identified in alcoholic beverages.
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These include methanol, diethylene glycol used as sweetener and chloroacetic acid or its bromine analogue, respiratory papillomatosis drug azide and salicylic acid, which are used as respiratory papillomatosis drug or bactericides Ough, Contaminants may also be present in alcoholic beverages. Contaminants are defined as substances that are not respiratory papillomatosis drug added but are present in alcoholic beverages due to production, manufacture, processing, preparation, treatment, packing, packaging, transport or holding, or as a result of environmental contamination.
Contaminants and toxins found in alcoholic beverages are nitrosamines, mycotoxins, ethyl carbamate, pesticides, thermal processing contaminants, benzene, and inorganic contaminants such as lead, cadmium, arsenic, copper, chromium, inorganic anions, and organometals IARC, In view of the potential carcinogenicity of acetaldehyde and its known respiratory papillomatosis drug properties, recent studies attempted to estimate exposure to acetaldehyde from alcoholic beverages outside ethanol metabolism at known levels of alcohol exposure.
Trends in consumption of alcoholic beverages Volume, pattern and quality of consumed alcohol are included in the description of differential exposure to alcohol.
Palliative radiotherapy is available in both of the Oncological Institutes, but the indicator related to this treatment is not available.
In —09, WHO conducted the Global Survey on Alcohol and Health, collecting data on alcohol consumption, alcohol-related harm and policy responses from its Member States. Total adult per capita consumption in litres of pure alcohol is defined as the total amount of alcohol consumed per person, taking into account recorded consumption i. Recorded adult per capita consumption is calculated from production, export and import data, or sales data.
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Unrecorded consumption is computed from representative surveys, specific empirical investigations or expert opinion. Overall, there is a wide variation in the volume of alcohol consumed across countries. As presented in Table 1.
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Apart from some countries in Africa and a few countries in other parts of the world, alcohol consumption in the other regions is generally lower. Table 1. Globally, men consume more alcohol than women. This is reflected in the differences in the number of lifetime abstainers, past year abstainers and former drinkers Table 1.
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A former drinker is a person who did respiratory papillomatosis drug consume any alcohol during the past year. Generally, the percentage of lifetime and past year abstainers is higher in women than in men. The prevalence of lifetime, past-year abstainers, and former drinkers are calculated from large representative surveys.
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Alcohol consumption remains low in the Eastern Mediterranean Region. Cancer in Humans 2. Description of cohort studies 2.
Studies in the general population Cohort studies are classified by the country in which the study was conducted Table 2. Since the previous Respiratory papillomatosis drug Monograph IARC,data on the association between alcohol consumption and risk respiratory papillomatosis drug cancer have been published from several cohorts, including updates of cohorts described previously Bongaerts et al.
Studies in special populations This group of studies is characterized by the assumption that the study subjects have a pattern of consumption of alcoholic beverages that is different from that of the general population, e. Because of the availability of national registries of populations, inpatients and cancer, these studies were largely performed in Scandinavian countries.
The estimation of risk in these individuals is not respiratory papillomatosis drug upon a comparison of exposed and unexposed subjects within the cohort, but with the expected rates of cancer in the general population.
Thygesen et al. Cancers of the upper aerodigestive tract 2. Cancer of the oral cavity and pharynx It was concluded in the previous IARC Monograph IARC, that consumption of alcoholic beverages is causally related to cancer of the oral cavity and pharynx, and that the risk increases in a dose-dependent manner.
Significant increases in risk were found with increasing amount of alcohol consumption in all studies Freedman et al.
In one case—control study conducted in Taiwan, China among patients attending a hospital clinic Yen et al. Friborg et al. In most studies an approximate threefold increased risk was found at relatively high levels of intake i.
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There is increasing evidence from recent cohort studies that risk may already be increased at more moderate intake, particularly in women Freedman et al. Consistent with many earlier studies, risks were found to be elevated among recent former drinkers, most likely due to ill respiratory papillomatosis drug directly related to the cancer or its precursors.
Studies have been hampered with low numbers of women at the highest levels of exposure.