Treatment for choroid plexus papilloma

It is characterized by anabnormal buildup of cerebrospinal fluid CSF in the cerebral ventricles and subsequent enlargement of the ventricles. Treatment for choroid plexus papilloma authors review current evidenceregarding hydrocephalus and propose an algorithm for hydrocephalus diagnosis.

treatment for choroid plexus papilloma

Conclusions: Quick diagnosis of hydrocephalus is important, antenatal if possible through non-invasive methods like MRI and 4D ultrasound. Currently, the best available treatment methods include endoscopic third ventriculostomy or placement of a ventriculoperioneal shunt.


In fetuses andinfants, when the cranial sutures are not yet fused,the most frequent clinical finding is represented bymacrocephaly [2,3]. Hydrocephalus remains a majorproblem in the pediatric pathology, especially ininfants, being the most frequent disorder treated bypediatric neurosurgeons [4]. Obstructive hydrocephalus or noncommunicatinghydrocephalus represents the consecutive excessivebuildup of CSF due to a mechanical blockage ofthe CSF at some point of the ventricular system. Typically, it is associated with increased intracranialpressure ICP [6].

Communicating hydrocephalus is caused eitherby an abnormal absorption of the CSF, or morerarely due to an increased production of CSF. Usually this type of hydrocephalus is associatedwith increased ICP [6].

Normal pressurehydrocephalus NPH consists of enlargedventricle size, butnormal ICP and mostcommonly occurs inthe adult population. Recently, Rekateet al. Takinginto account the site of the obstruction, there are sixtypes of hydrocephalus: foramen of Monro, aqueductof Treatment for choroid plexus papilloma, outlets of fourth ventricle, basal cisterns,arachnoid granulations, venous outflow [7].

Hypertensionis associated with an increased risk in hydrocephaluspresenting with intracerebral hemorrhage OR 1. The Asianpopulation appears treatment for choroid plexus papilloma have a lower risk for congenitaland infantile hydrocephalus [8,9]. Myelomeningocele isresponsible for almost a quarter of the cases [8,9,11].

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Chiari malformations produce an obstructive formof hydrocephalus by blocking the flow of the CSF inthe posterior fossa [6]. Other CNS malformationswhich might cause hydrocephalus are the Dandy-Walker malformation, in which up to 90 percent ofthe patients develop hydrocephalus due Luschka andMagendie foramina atresia and also a malformationof the vein of Galen, in which the presence of thearterial pressure in the venous system might beresponsible for the hydrocephalus [6].

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Neural tubedefects can be prevented by administering virus papiloma humano causas acidto women before conception [12]. The most frequent genetic disorders associatedwith hydrocephalus are Patau syndrome also known astrisomy 13, main abnormalities include microcephaly,meningomyelocele, polydactyly and kidney andheart defect, Edwards syndrome or trisomy 18, ischaracterized by small infants with heart and cerebralmalformations such as ventricular septal defect andmicrocephaly and the triploid syndrome very raregenetic disorder with the central nervous systemand the skeletal system being the most affected;abnormalities treatment for choroid plexus papilloma Arnold-Chiari malformationsand agenesis of the corpus callosum [10].

X-linked hydrocephalus with aqueductal stenosisrepresents the most frequent form of congenitalhydrocephalus, being encountered in up to 5 percentof the cases with congenital hydrocephalus [10].

Isolated hydrocephalus is commonly producedby aqueduct stenosis, which can result either from acongenital tapering of the aqueduct or following anintrauterine infection which led to inflammation [6]. Contradictory data have been published regardingthe role of maternal antidepressants in the appearanceof hydrocephalus [6,13]. Posthemorrhagichydrocephalus occurs when blood accumulates inthe subarachnoid space or the ventricular systemleading to an inflammatory response and fibrosis andsubsequent impaired absorption of the CSF [6].

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Insome cases, the flow of the CSF can also be obstructed. Headaches usually occur inthe morning because the venous pressure is higherwhen the patient is lying down, thus increasing theICP and reducing the CSF absorption [16].

Treatment for choroid plexus papilloma vomiting can also occur, especially when theincreased ICP arises in the posterior fossa [16].

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Ifthe sutures are not closed, frontal bossing can existand ICP signs might be absent [16]. The sunseteyes represent a characteristic sign for raised ICP, inwhich the eyes are driven downward fig. Scalpveins are dilated and are forming a frontotemporalnetwork of veins pressure fig. This sign is usually revealed by the parents [16].

Severe forms of hydrocephalus are associated withlethargy, motor including spasticity due to thestretching of the motor cortex fibers and cognitivedysfunctions [14,16]. Children classically treatment for choroid plexus papilloma with the same signsand symptoms but without the frontal bossing [14]. Ventriculomegaly can initially be assessed byperforming an antenatal 4D ultrasonography.

Thediameter of the lateral ventricles should be measuredat the level of the vaccino papilloma virus uomo 40 anni. The diameter is usuallyconstant between 15 and 40 weeks of gestation anddoes not exceed 10 mm [19]. Mild ventriculomegaly is considered when the atria size exceeds 10 mm, andsevere ventriculomegaly when the ventricular atriasize is greater than 15 mm [20,21].

A qualitativediagnostic method for ventriculomegaly is adecreased choroid to CSF ratio, but this method ismore subjective [22].

It is imperative to performsuch procedures in specialized centers by specializedmedical personal, in order to maximize the specificityand sensitivity of the investigation [23].

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Following the diagnosis of ventriculomegaly, itis necessary to look for other abnormalities and toidentify the underlying cause of ventriculomegaly.

Additional abnormalities are present in 10 to 76percent of cases the rate being higher in case ofsevere ventriculomegaly and further imaging examsshould be performed to evaluate more regions, suchas corpus callosum, thalami, cerebellum, the 3rd and4th ventricles [21,24—26]. One possible cause of ventriculomegaly is aninfection of the central nervous system.

Signs ofinfection can be seen when a sonographic exam isperformed and include periventricular or intracerebralcalcifications [23].

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Amniotic fluid polymerase chainreaction PCR treatment for choroid plexus papilloma should be performed tofurther elucidate the presence of infection with themost common pathogens being cytomegalovirus CMVtoxoplasma and parvovirus [23,27,28].

In order to determine the fetal karyotype, it isrecommended to perform an amniocentesis at morethan 15 gestational weeks [23].

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An abnormal fetalkaryotype can be present in up to 4. In fetuses with normal karyotype or no otherplausible cause, a fetal MRI exam must be performed to detect possible cortical abnormalities fig. Itis usually done at 22 to 24 gestational weeks [23].

The usage of MRI is limitedwhen a chromosomal aberration is present, becausein almost all of the cases there is a poor neurologicaloutcome, indifferent of the imaging result [23]. Follow-up ultrasound examinations between 28and 34 weeks of gestation can reveal the regression orprogression of ventriculomegaly [23]. In 13 percent of the cases an initially undetectableabnormality was revealed at the follow-up exam [31].

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The CT scan remains a reliable investigationbecause it is readily available and quick to perform,particularly when there are signs of increasedICP Grade Irepresent a mild dilatation of the ventricles, whilegrade IV is characterized by an extreme form ofhydrocephalus, with the cerebral mantle reduced to cm fig. Treatment for choroid plexus papilloma main disadvantage of the CTscan is the exposure to radiations [33].

If there aresign of hydrocephalus a further MRI exam is usuallyrequired [16]. A funduscopic examination is mostlyneeded in older children to assess the presence ofpapilledema [16,34].

Medical management of hydrocephalus hasproven ineffective or has a short term usability [14,28]. Surgical treatment is mandatory for acutehydrocephalus and the main treatment options consistof endoscopic third ventriculostomy or placement of aCSF shunt.

Unstable patients with rapid progressivehydrocephalus represent an emergency and requirethe placement of a temporary external ventriculardrainage, but it must be taken into account treatment for choroid plexus papilloma everyexternal communication has a high risk of infectionso the external ventricular drain treatment for choroid plexus papilloma be removed orconverted to a ventriculo-peritoneal shunt as soon as possible [14,35].

Table 1 illustrates the advantages anddisadvantages of the main therapeutic methods. The most commontype of shunt used is the ventriculo-peritoneal one,which drains the CSF from the ventricles to theperitoneum fig. Radiologic investigations are usedto assess the viability of the drainage and its properplacement [36,37].

Most common complications of CSF shunts aremechanical and infectious. Mechanical complications consist mainly ofshunt blockage. It usually arises in the first year afterplacement and the most common obstruction siteis the ventricular catheter [38,39]. Also, during thegrowth of the child, there is a chance of ventriculoperitonealshunt disruption [14].

Between percent of shunt placementprocedures suffer infectious complication, mostfrequently in the first six months after placementand can lead to devastating consequences, such aspoor cognitive status and death [35,38].

Congenital anomalies of the heart and vessels 10 Heart malformations are determined by various factors, some with severe movement disorders and oxygen that are incompatible with life, other compatible although initially not generally allow a long-term survival. They occur in animals as lack or excess malformations by malformations of position, or structural alterations septs or the heart valves. Shows theoretical and practical treatment for choroid plexus papilloma Acardia total lack of heartlack of closing the pericardial sac, diplocardia double heart multiplicitas cordis multiple cordsdextrocardia heart on the right side of the mediastinumcardiac ectopia presence of heart in the cervical region, pectoral or abdominaletc. Septs structural defects are common to all species. The total or partial lack thereof, determines the appearance of cords bilocular right or left respectively upper and lower or bilocular cords biventricular, trilocular, biatriale or malformations incompatible with life.

Some studiessuggest that prophylactic antibiotics reduce the risk ofinfection with up to 50 percent [40—42]. Afterconfirming the sterility of 3 consecutive CSF samples,a new VP shunt can be positioned on the contralateralside [43]. Endoscopic third ventriculostomy fig. The firstendoscopic third ventriculostomy was performed in by Mixter [45]. When choosing the optimaltreatment, it must be taken into account that ETVhas higher failure rates in you nger patients andalso this procedure has a greater surgical risk thanthe ventriculo-peritoneal shunt insertion [46].

Ifthe ETV procedure fails, the next step virus papiloma humano red christus to placea shunt because repeating the ETV in the acutephase will most probably be unsuccessful [15]. ETVcomplications comprise of meningitis, cranial nervesinjury and even basilar artery perforation [47,48]. Elective preterm delivery was proposed forfetuses with severe ventriculomegaly in order toperform a technique to reduce the pressure on thedeveloping brain and stop the progressive braindamage, but no there is no data to treatment for choroid plexus papilloma the benefitof treatment for choroid plexus papilloma procedure [23].

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Cesarean delivery is indicated only whenventriculomegaly is associated with macrocephaly andshould be performed when the head circumference isgreater than 40 cm, but it may vary depending on thesize of the maternal pelvis and the gestational age [23].

In infants and children, the vital outcome dependson prematurity, presence or absence of respiratoryand CNS infections, nutrition and other organic ormetabolic disorders [14]. Functional outcome relies mainly on the severityof the hydrocephalus, the destruction of the cerebralparenchyma and also on the time passed betweenthe first signs of hydrocephalus and diagnosis andsurgical treatment [14].

Increased intracranialpressure syndrome and altered visual function arealso factors that influence the functional outcome,including the cognitive function and the IQ score.

Anyneuropsychological or ophthalmologic change mustbe promptly evaluated and fundoscopy and radiologicinvestigation must be performed [14]. Because of theirradiation level, CT scans must be avoided wheneverpossible and MRI or ultrasound exams should beused instead. Themost common deficits were cognitive Intercurrent infections, long sunexposure, cerebral trauma and abdominal surgery arefactors that can lead to the decompensation of thehydrocephalus.

Because of this,prevention of neural tube defects by prenataladministration of folic acid is important and antenataldiagnosis and close follow-up are essential. Even with all the available therapeutic efforts,this major problem treatment for choroid plexus papilloma CSF production, reabsorptionand circulation cannot be fully treated and in suchconditions the main objective is prevention i.

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