The biologic behavior of squamous cervical carcinoma after neoadjuvant therapy NAT according to immunohistochemical expression of E-cadherin and CD44v6 Mihaela Madalina Gavrilescu, Raluca Balan, Viorel Scripcariu, Dan Ferariu, Ludmila Lozneanu, Diana Popovici, Cornelia Amalinei Abstract The hpv squamous epithelial cells of neoadjuvant therapy in cervical carcinoma has been well demonstrated, although the cellular mechanisms of different response to this treatment have not been thoroughly investigated.
Synevo HPV genotipare în salivă Lei Informaţii generale şi recomandări Cancerele capului şi gâtului — în majoritatea cazurilor hpv squamous epithelial cells cu celule scuamoase HNSCC — Head and Neck Squamous Cell Carcinoma, în literatura engleză includ neoplazii ale cavităţii orale, orofaringelui, hipofaringelui, laringelui, tractului sinonazal şi nazofaringelui. În India constituie cea mai frecventă formă de cancer. Cu toate acestea, în ultima decadă, date clinice şi epidemiologice au documentat asocierea dintre infecţia HPV papiloma virus uman a cavităţii orale şi OSCC2;3;4;5. Infecţia genitală cu HPV reprezintă cea mai frecventă boală virală cu transmitere sexuală şi este implicată în marea majoritate a cazurilor de cancer cervical.
The aim of our study was to assess the correlations between the alterations in E-cadherin and CD44v6 immunoexpression in cervical carcinoma, as a tool of evaluation the response to neoadjuvant therapy and its prognostic significance.
The intensity of CD44v6 immunoexpression was higher in more aggressive tumors and E-cadherin immunoexpression was approximately constant among the cases with neoadjuvant therapy.
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Our results demonstrate that the evaluation of CD44v6 immunoexpression in cervical carcinomas is useful for the assessment of tumor response to neoadjuvant therapy and of tumor aggressiveness. The high level of E-cadherin immunoexpression in tumors with neoadjuvant therapy reflects its involvement in the prevention of HPV oncoproteins action, with benefits on the outcome. A larger group of patients and a panel of antibodies, including CD4 and COX2, could provide a better characterization of the tumor response to neoadjuvant therapy, with papillomavirus pas grave positive prognosis impact.
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Cell adhesion system and human cancer morphogenesis. Cancer Sci ; HPV16 E7 oncogene expression in normal human epithelial cells causes molecular changes indicative of an epithelial to mesenchymal transition. Virology ; 1 Tumor biomarkers in cervical cancer: focus on Ki proliferation factor and E-cadherin expression.
Significance of E-cadherin, beta-catenin, and vimentin expression as postoperative prognosis indicators in cervical squamous cell carcinoma. Hum Pathol ;