In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of the head and neck, causing alterations in DNA. It has been demonstrated that the human papillomavirus HPV type 16, a subtype of the human papillomavirus, is present in the oropharyngeal carcinomas of non-smokers patients inclusive. HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type protein RBP involved in the regulation of proliferation and cell death.
Aim: To implement the HPV genotyping method of fresh head and neck cancer samples in our laboratory. More than half of the patients recognized being chronic alcohol and tobacco users.
Vegetațiile veneriene, negii venerieni sau genitali, condiloamele sau verucile genitale, toate aceste denumiri sunt sinonime ale infecției cu virusul HPV. Cu peste de tulpini descoperite în momentul actual, afecțiunile acestui virus pot fi simptomatice sau nu. Cea mai frecventă manifestare a virusului HPV este reprezentată de negii apăruți în diferite zone ale corpului, cum ar fi la nivelul mâinilor, picioarelor sau în zona genitală. Persoanele care se infectează cu virusul HPV se pot vindeca cu ajutorul medicației, fără să rămână cu sechele.
Conclusions: The genotyping method was validated according to kit instructions. To get a general idea on the prevalence of HPV genotypes in head and neck cancer in our region we tested a very small number of samples. Ferlay J, Soerjomataram I et al. Comprehensive control of human papillomavirus infections and related diseases.
Venuti A, Paolini F. Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas.
Department of Ophthalmology, Grigore T. E-mail: moc. We report the detection of HPV 52 in a sample taken from a year-old patient with squamous cell carcinoma of the conjunctiva of the left eye. The method used for the detection of HPV was real time polymerase chain reaction. The evolution was favorable after surgical removal of the tumor and the patient was explained that long-term follow-up is essential to avoid recurrence.
Ursu RG, Danciu M et al. Virol J.
Human papillomavirus prevalence in invasive laryngeal cancer in the United States. Shanesmith R, Allen RA et al.
Comparison of 2 line blot assays for defining HPV genotypes in oral and oropharyngeal human papillomavirus (hpv) infection of the larynx has been associated with cell carcinomas. HPV genotype distribution in oral and oropharyngeal squamous cell carcinoma using seven in vitro amplification assays.
Garnaes E, Kiss K et al.
Human papillomavirus 52 positive squamous cell carcinoma of the conjunctiva
A high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, the largest registry-based study to date. Time trends in the prevalence of HPV in oropharyngeal squamous cell carcinomas in northern Spain Low human papillomavirus prevalence in head and neck cancer: results from two large case-control studies in high-incidence regions.
Human Papillomavirus and Head and Neck Cancer
Westra WH. Heiduschka G, Grah A et al. Masterson L, Moualed D et al. De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma: a systema-tic review and meta-analysis of current clinical trials.
- According to some recent studies, the HPV infection may also increase the risk of cardiovascular diseases.
- Human papillomavirus 52 positive squamous cell carcinoma of the conjunctiva
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- HPV (Human Papilloma Virus) | ARAS – Asociatia Romana Anti-SIDA