Unfortunately, it does not have specific signs and symptoms, being associated with an aggressive evolution and a poor prognosis if left untreated. Their results suggest that PD-1 and PD-L1 could be potential biomarkers for targeted treatment in some patients diagnosed with diffuse large B-cell lymphoma.
Malignant lymphomas of the head and neck may raise therapeutic difficulties. OIU, Vlad D.
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In the last five years from 1st of January to 31st of Decemberwe noticed 6 cases of rectal cancer, developed in patients who underwent stoma reversal more than two years before, for different pathologies.
The objective of the study. That was a starting point to analyze whether the restoration of a total digestive diversion, well known to improve life quality, also increases the risk of malignancy.
Material and methods. Our study showed that stoma reversal increase the risk of developing a rectal malignancy two years from restoration.
We recommend annual control by recto-sigmoidoscopy both in patients with terminal permanent colostomy and in those with stoma reversal, in order to early discover a subsequent rectal cancer.
PD-L1 expression most often correlates with a poor prognosis and a PD-1 regulatory factor that mediates immunosuppression. The objective of this study was to describe the correlation between PD-1 and PDL-1 with survival in patients with the diagnosis of diffuse large B cell lymphoma.
We found that there is a tendency of decreased survival and therapeutic response in DLBCL patients, with both an intense and weak PD-L1 positivity in tumor cells. PD-1 low positivity was associated in higher percentage with relapse and treatment unresponsiveness.
ГЛАВНАЯ РАЗНИЦА МЕЖДУ ЭЛЕМЕНТАМИ, ОТВЕТСТВЕННЫМИ ЗА ХИРОСИМУ И НАГАСАКИ Соши размышляла вслух: - Элементы, ответственные за Хиросиму и Нагасаки… Пёрл-Харбор.
Conclusions: Our data suggested that PD-L1 expression correlates with a poor clinical response although it is not an independent prognostic marker and PD-1 represents a favorable prediction factor for survival. Drug therapy in autoimmune thyroiditis Author : Michael I.
Autoimmune thyroiditis AIT is one of the unsolved problems of modern endocrinology, the etiology and pathogenesis being still insufficiently known. To study the effects of substitution, antioxidant and lymph-drainage therapy on the structure and function of the thyroid gland in patients with AIT and hypothyroidism.
We have identified 2 groups of patients with AIT and subclinical hypothyroidism. The first group — control group — included 20 patients who received substitution therapy with thyroxine.
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The second group included 33 patients who received a comprehensive treatment with thyroxine, alpha papillary thyroid cancer level 6 acid and Lymphomyosot. The use of substitution therapy with thyroxine and the proposed antioxidant and lymph drainage therapy in patients with AIT led to the improvement of the structure of the gland, reduced the activity of peroxide oxidation processes and the activity of pro-inflammatory cytokines, increased the level of antioxidant defense enzymes, normalized the number of aniline-positive lymphocytes, improved the lymphatic drainage function of the gland.
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Our results sustain the effectiveness of the proposed method of complex treatment in patients with autoimmune thyroiditis.
Ghrelin level and types of eating behavior when combined with irritable bowel syndrome, arterial hypertension and obesity Author : Vasyl G.
However, its cardioprotective effect, as well as vasodilatory action and participation in arterial pressure regulation, are not sufficiently studied.
To study fasting and postprandial ghrelin levels papillary thyroid cancer level 6 eating behavior in patients with comorbidities such as irritable bowel syndrome, arterial hypertension, and obesity. Materials and methods. The study included 24 patients with irritable bowel syndrome, constipation and normal body mass index, 18 patients with arterial hypertension and obesity, and 54 patients with irritable bowel syndrome, constipation, arterial hypertension, and obesity.
Blood pressure monitoring was performed in all patients and fasting and postprandial ghrelin levels in blood serum were measured, as well as eating behavior type, using the Dutch Eating Behavior Questionnaire.
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Results of hour blood pressure monitoring showed a more significant rise in blood pressure, as well as a predominance of the non-dipper profile, encountered in The increased level of postprandial serum ghrelin in patients with this comorbid pathology contributes to the predominance papillary thyroid cancer level 6 and emotional types of eating behavior, which were found in The studied combined pathology irritable papillary thyroid cancer level 6 syndrome with constipation, arterial hypertension, and obesity is accompanied by higher blood pressure, non-dipper blood pressure profile predominance, increased postprandial ghrelin level and eating disorders.
High-grade serous carcinoma of the ovary is an aggressive form of cancer, with unknown precursor lesions and often delayed diagnosis because of non-specific, mild symptoms.
We performed a clinical-pathological study of ovarian high-grade serous carcinomas, in order to evaluate morphological and new immunohistochemistry characteristics of this malignancy. This is a retrospective cancer la san nodul of 10 cases of ovarian high-grade serous carcinoma.
Mean age was Maximum tumor diameter was 16 cm. We noticed one case with pleural metastasis M1.
It is estimated that the death rate of TC has slowly increased from 0. Therefore, efforts are being made in order to stop the increasing incidence and genetic alterations are thoroughly studied. One of the most recent incriminated factors in TC etiology and physiopathology is vitamin D deficiency.
The majority of patients with ovarian high-grade serous carcinomas presented with extraovarian extension and were characterized by high mitotic index, rare presence of psammoma bodies, AR expression Bilateral breast carcinoma — a study of patients admitted in a university emergency hospital Author : Oana C. Breast carcinoma represents the leading cause of oncologic mortality among women worldwide.
Bilateral breast carcinoma is a distinct pathologic entity, with particular prognostic and therapeutic implications. The objective of the study was to determine the histologic and immunohistochemical characteristics of patients with bilateral breast carcinoma admitted in a university emergency hospital from Bucharest, Romania. We analyzed breast carcinoma specimens registered as bilateral in the Department of Pathology of the University Emergency Hospital, Bucharest, Romania, betweenand studied their histologic and molecular features in the clinical context obtained from our hospital database.
All the analyzed papillary thyroid cancer level 6 were postmenopausal women.