Papillary thyroid cancer variants


Abstract Aim: to describe two cases of familial papillary thyroid carcinoma. Material and methods: patients were investigated by fine needle biopsy, MRI imaging and tumor biopsy, first case and histological examination of colonic and thyroid tumors first case and histological examination of thyroid tumor second case.

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Results and discussion: case presentation: first case, 68 years old man had a colonic polyposis attenuated form with only a few polyps and a thyroid nodule.

After hemicolectomy for a supposed colonic carcinoma with liver and lung metastases, histological examination revealed no malignant colonic disease. Two month later the diagnosis of invasive thyroid tumor with lymph node metastases was made, but only an open biopsy was done because tumor invasiveness demonstrated on MTI imaging.

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The biopsy identified a papillary thyroid carcinoma. Case 2: the son of the patient papillary thyroid cancer variants years old without known diseases was invited to be assessed for thyroid disease. Ultrasound examination discovered a large nodule with microcalcifications.

Microscopic examination done after total thyroidectomy revealed a cribriform morular variant of papillary thyroid carcinoma, a variant that is known to be associated with FAP. Radioiodine ablation was made followed by suppressive thyroxine treatment.

[Differentiated thyroid cancer--peculiar morphological and clinical forms].

In the second case adenomatous polyposis was not found yet. In our knowledge these are the first cases of familial thyroid papillary thyroid cancer variants carcinomas in our setting.

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Familial history allowed an earlier diagnosis and a good management of the disease in the second case. Conclusions: according to the literature and our first experience, screening for thyroid cancer must be done in all patients with FAP and in those with a FAP proband in the family.

  • Endocrine cancer specialists
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Nosé V. Endocr Pathol. Modern Pathology ; SS Cavaco BM.

  • Consecuencias del virus del papiloma humano en mujeres y hombres
  • DNMT1 expression in papillary thyroid carcinoma | ECE
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DNMT1 expression in papillary thyroid carcinoma

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Sinonimele și antonimele papillary în dicționarul de sinonime Engleză

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Nicolau Institute of Virology, Bucharest, Romania. Introduction: In human cancer cells DNMTs are responsible for both de novo and maintenance methylation of tumor suppressor genes. Design: 49 patients aged 10–82 years hospitalized for thyroidectomy were included between January and July

Ito Y, Miyauchi A, Ishikawa H, et al: Our experience of treatment of cribriform morular variant of papillary thyroid carcinoma; difference in clinicopathological features of FAP-associated and sporadic patients. Mc Donald TJ. Journal of Oncology.

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