Papillomas nostril.

Data is Klimicsh 2 and from authoritative database Effect on fertility: via inhalation route Endpoint conclusion: Effect on fertility: via dermal route Endpoint conclusion: Additional information Reproductive toxicity study Data available from papillomas nostril studies were reviewed to determine the reproductive toxicity of testchemical.

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The studies are as mentioned below: Study 1 In a 28 days repeated dose toxicity study, papillomas nostril effect of the test papillomas nostril was evaluated in male and female Sprague Dawley rats. No significant changes in were detected in hematology,clinical biochemistry,mortality ororgan weight, and no effects were observed in water consumption,opthalmoscopic examination or locomotor activity.

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Study 2 In a chronic study Male and female CD-1 simptome ale parazitilor intestinali administered test chemical in diet at levels of 0 control0. The papillomas nostril were observed for clinical sign,mortality,body weight ,food intake, hematology,gross and histopathology There were no significant differences in mortality papillomas nostril the control and treated groups. Mean body weights of high-dose groups showed significant decreases compared with the controls.

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Microscopic findings in the kidneys of treated mice included the nephrosis, papillomas nostril or hyperplasia of transitional epithelium of renal pelvis or papilla.

In the bladder of treated mice, hyperplasia or squamous metaplasia of transitional epithelium and one transitional cell papilloma were observed.

Papillomas nostril decreases in the incidence of spontaneous lesion in the male or female reproductive system were recognized. Thus, comparing this value with the criteria of CLP regulation test material is not likely to classify as reproductive toxicant. When rats were treated with test chemical orally.

papillomas nostril

Thus, comparing this value with the criteria of CLP regulation test chemical is not likely to classify as reproductive and developmental toxicant. Link to relevant study records Reference.

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